反应详情

To a stirring solution of ethyl 5-chloro-2-(quinolin-6-yl)benzoate (0.244 g, 0.78 mmol) in 1:1:1 THF/EtOH/H2O (21 ml) at RT was added LiOH—H2O (0.164 g, 3.91 mmol). The resulting reaction mixture was stirred at RT overnight. Solvent was removed under reduced pressure and the residue was diluted with H2O (10 mL). The aqueous solution was acidified to pH˜4 with 3M HCl and extracted with EtOAc (3×30 mL). The combined organic layers were washed with brine (20 mL), dried (MgSO4) and concentrated to afford 5-chloro-2-(quinolin-6-yl)benzoic acid (0.201 g, 91% yield) as a white solid. MS (ESI) m/z: 284.0 (M+H+).

1. customThe resulting reaction mixture
2. customSolvent was removed under reduced pressure
3. additionthe residue was diluted with H2O (10 mL)
4. extractionextracted with EtOAc (3×30 mL)
5. washThe combined organic layers were washed with brine (20 mL)
6. dry with materialdried (MgSO4)
7. concentrationconcentrated