4-Nitro-3-trifluoromethylphenol → Rac-(2-isopropoxy-5-methanesulfonyl-phenyl)-[3-(4-nitro-3-trifluoromethyl-phenoxy)-pyrrolidin-1-yl]-methanone

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Reaction Steps

Prepared in analogy to Example 4 from rac-(3-hydroxy-pyrrolidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone (Example 9(a)) and 5-hydroxy-2-nitrobenzotrifluoride. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 56%). MS (m/e): 517.5 (M+H+, 100%).

Provenance & Evidence