3-Fluoro-5-(trifluoromethyl)phenol → HCID 58673075, compound

HRID 1711754Notes

Reaction equation

HRID 1711754 reaction equation
[OH:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:14]=[C:13]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=2[O:19][CH:20]([CH3:22])[CH3:21])=[O:8])[CH2:3]1.[F:23][C:24]1[CH:25]=[C:26](O)[CH:27]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:29]=1>>[F:23][C:24]1[CH:25]=[C:26]([CH:27]=[C:28]([C:30]([F:31])([F:32])[F:33])[CH:29]=1)[O:1][CH:2]1[CH2:6][CH2:5][N:4]([C:7]([C:9]2[CH:14]=[C:13]([S:15]([CH3:18])(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=2[O:19][CH:20]([CH3:22])[CH3:21])=[O:8])[CH2:3]1

Participants

3

Reactant 2

HCID 27375873-Fluoro-5-(trifluoromethyl)phenolHCID 58673070Rac-(3-hydroxy-pyrrolidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone

Product 1

HCID 58673075HCID 58673075, compoundYield 45%

Procedure

Prepared in analogy to Example 4 from rac-(3-hydroxy-pyrrolidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone (Example 9(a)) and 3-fluoro-5-(trifluoromethyl)phenol. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 45%). MS (m/e): 490.1 (M+H+, 100%).

Workup

  1. customThe crude material was purified by reversed phase HPLC (acetonitrile/water)

Sources & evidence

ORD record
ord-2c7cbef3b6c24bfc814d6086b8c160e1
Source dataset
uspto-grants-2010_09
Patent number
US07790763B2

Reaction notes

Loading…