HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Fluoro-5-(trifluoromethyl)phenol → HCID 58673075, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Fluoro-5-(trifluoromethyl)phenol | HCID 2737587 | — |
| Reactant | Rac-(3-hydroxy-pyrrolidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone | HCID 58673070 | — |
| Product | HCID 58673075 | HCID 58673075 | 45% |
Reaction Steps
Prepared in analogy to Example 4 from rac-(3-hydroxy-pyrrolidin-1-yl)-(2-isopropoxy-5-methanesulfonyl-phenyl)-methanone (Example 9(a)) and 3-fluoro-5-(trifluoromethyl)phenol. The crude material was purified by reversed phase HPLC (acetonitrile/water) to yield the title compound as an amorphous white solid (yield 45%). MS (m/e): 490.1 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790763B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-2c7cbef3b6c24bfc814d6086b8c160e1 |
| Source note | uspto-grants-2010_09 |