HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[3-(Trifluoromethyl)phenoxy]azetidine → (2-Isopropoxy-5-methanesulfonyl-phenyl)-[3-(3-trifluoromethyl-phenoxy)-azetidin-1-yl]-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[3-(Trifluoromethyl)phenoxy]azetidine | HCID 11138538 | — |
| Reactant | 2-Isopropoxy-5-methylsulfonylbenzoic acid | HCID 21100237 | — |
| Product | (2-Isopropoxy-5-methanesulfonyl-phenyl)-[3-(3-trifluoromethyl-phenoxy)-azetidin-1-yl]-methanone | HCID 11712232 | 7% |
Reaction Steps
Prepared in analogy to Example 1 from 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example A1) and 3-(3-trifluoromethyl-phenoxy)-azetidine. The crude material was purified by chromatography (methanol/dichloromethane) to yield the title compound as an amorphous white solid (yield 7%). MS (m/e): 458.2 (M+H+, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07790763B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-1fd7b0257f184031aa4e7c70e07384d7 |
| Source note | uspto-grants-2010_09 |