反应详情

温度

85 °C

2-Bromo-2′,4′-difluoroacetophenone (7.50 g, 31.9 mmol) and thiazol-2-amine (3.20 g, 31.9 mmol) were added to EtOH (85 mL) and then heated to about 85° C. in an oil bath for about 16 h. The mixture was cooled in ice water, filtered, and washed with EtOH. Drying under vacuum at about 60° C. provided the title compound (5.84 g, 77%): LC/MS (Table 1, Method a) Rt, =2.68 min; MS m/z: 237.3 (M+H)+.

1. filtrationfiltered
2. washwashed with EtOH
3. customDrying under vacuum at about 60° C.