Pyridine → STK299624

HRID 1711801Notes

Reaction equation

HRID 1711801 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([NH2:15])[CH:14]=1)[C:5]([NH:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6].[CH3:16][CH:17]([CH3:22])[CH2:18][C:19](Cl)=[O:20].CN1[C:28](=[O:29])[CH2:27][CH2:26][CH2:25]1.[Li+].[Cl-].N1C=CC=C[CH:33]=1>>[C:8]([NH:7][C:5](=[O:6])[C:4]1[CH:12]=[C:13]([NH:15][C:19](=[O:20])[CH2:18][CH:17]([CH3:22])[CH3:16])[CH:14]=[C:2]([NH:1][C:28](=[O:29])[CH2:27][CH:26]([CH3:33])[CH3:25])[CH:3]=1)([CH3:11])([CH3:10])[CH3:9]

Participants

6

Reactant 5

HCID 1049PyridineHCID 13387N-methyl-2-pyrrolidoneHCID 66054Isovaleryl chlorideHCID 433294Lithium ChlorideHCID 1369592HCID 1369592, compound

Product 1

HCID 1342795STK299624

Procedure

from 0.50 g (2.41 mmol) of 3,5-diamino-N-t-butyl-benzamide, 0.68 g (5.64 mmol) of 3-methylbutyric acid chloride, 30 ml of NMP, 5 ml of pyridine and 0.1 g of LiCl according to Method A.

Sources & evidence

ORD record
ord-a6d1370b968a426d8af7e918779d0f25
Source dataset
uspto-grants-2010_09
Patent number
US07790793B2

Reaction notes

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