Pyridine → HCID 58903232, compound

HRID 1711802Notes

Reaction equation

HRID 1711802 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:12]=[C:13]([NH2:15])[CH:14]=1)[C:5]([NH:7][C:8]([CH3:11])([CH3:10])[CH3:9])=[O:6].[CH:16]1([C:21](Cl)=[O:22])[CH2:20][CH2:19][CH2:18][CH2:17]1.CN1[C:29](=[O:30])[CH2:28][CH2:27][CH2:26]1.[Li+].[Cl-].N1C=CC=[CH:35][CH:34]=1>>[C:8]([NH:7][C:5](=[O:6])[C:4]1[CH:12]=[C:13]([NH:15][C:21]([CH:16]2[CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:22])[CH:14]=[C:2]([NH:1][C:29]([CH:28]2[CH2:35][CH2:34][CH2:26][CH2:27]2)=[O:30])[CH:3]=1)([CH3:11])([CH3:10])[CH3:9]

Participants

6

Reactant 5

HCID 1049PyridineHCID 13387N-methyl-2-pyrrolidoneHCID 78284Cyclopentanecarbonyl chlorideHCID 433294Lithium ChlorideHCID 1369592HCID 1369592, compound

Product 1

HCID 58903232HCID 58903232, compound

Procedure

from 0.50 g (2.41 mmol) of 3,5-diamino-N-t-butyl-benzamide, 0.75 g (5.66 mmol) of cyclopentanecarbonylchloride, 30 ml of NMP, 5 ml of pyridine and 0.05 g of LiCl according to method A.

Sources & evidence

ORD record
ord-712c898738fd4b09801364dd4106bba4
Source dataset
uspto-grants-2010_09
Patent number
US07790793B2

Reaction notes

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