Pyridine → HCID 58903281, compound

HRID 1711803Notes

Reaction equation

HRID 1711803 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([NH2:16])[CH:15]=1)[C:5]([NH:7][CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])=[O:6].[CH3:17][CH:18]([CH3:23])[CH2:19][C:20](Cl)=[O:21].CN1[C:29](=[O:30])[CH2:28][CH2:27][CH2:26]1.[Li+].[Cl-].N1C=CC=C[CH:34]=1>>[CH3:12][CH:10]([CH3:11])[CH2:9][CH2:8][NH:7][C:5](=[O:6])[C:4]1[CH:3]=[C:2]([NH:1][C:20](=[O:21])[CH2:19][CH:18]([CH3:23])[CH3:17])[CH:15]=[C:14]([NH:16][C:29](=[O:30])[CH2:28][CH:27]([CH3:34])[CH3:26])[CH:13]=1

Participants

6

Reactant 5

HCID 1049PyridineHCID 13387N-methyl-2-pyrrolidoneHCID 66054Isovaleryl chlorideHCID 433294Lithium ChlorideHCID 61092537HCID 61092537, compound

Product 1

HCID 58903281HCID 58903281, compound

Procedure

from 0.50 g (2.26 mmol) of 3,5-diamino-N-(3-methylbutyl)-benzamide, 0.64 g (5.31 mmol) of 3-methylbutyric acid chloride, 30 ml of NMP, 5 ml of pyridine and 0.05 g of LiCl according to Method A.

Sources & evidence

ORD record
ord-48d4ee09215e4420b3b628f0bc066e46
Source dataset
uspto-grants-2010_09
Patent number
US07790793B2

Reaction notes

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