Pyridine → HCID 58903241, compound

HRID 1711804Notes

Reaction equation

HRID 1711804 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([NH2:16])[CH:15]=1)[C:5]([NH:7][CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])=[O:6].[CH:17]1([C:22](Cl)=[O:23])[CH2:21][CH2:20][CH2:19][CH2:18]1.CN1[C:30](=[O:31])[CH2:29][CH2:28][CH2:27]1.[Li+].[Cl-].N1C=CC=[CH:36][CH:35]=1>>[CH3:12][CH:10]([CH3:11])[CH2:9][CH2:8][NH:7][C:5](=[O:6])[C:4]1[CH:3]=[C:2]([NH:1][C:22]([CH:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:23])[CH:15]=[C:14]([NH:16][C:30]([CH:29]2[CH2:36][CH2:35][CH2:27][CH2:28]2)=[O:31])[CH:13]=1

Participants

6

Reactant 5

HCID 1049PyridineHCID 13387N-methyl-2-pyrrolidoneHCID 78284Cyclopentanecarbonyl chlorideHCID 433294Lithium ChlorideHCID 61092537HCID 61092537, compound

Product 1

HCID 58903241HCID 58903241, compound

Procedure

from 0.50 g (2.26 mmol) of 3,5-diamino-N-(3-methylbutyl)-benzamide, 0.70 g (5.28 mmol) of cyclopentanecarbonylchloride, 30 ml of NMP, 5 ml of pyridine and 0.05 g of LiCl according to Method A.

Sources & evidence

ORD record
ord-5aa1b103911141039c94bf10e24cb4dd
Source dataset
uspto-grants-2010_09
Patent number
US07790793B2

Reaction notes

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