Pyridine → HCID 58903278, compound

HRID 1711805Notes

Reaction equation

HRID 1711805 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([NH2:16])[CH:15]=1)[C:5]([NH:7][CH2:8][CH2:9][CH:10]([CH3:12])[CH3:11])=[O:6].[CH:17]1([C:23](Cl)=[O:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1.CN1[C:31](=[O:32])[CH2:30][CH2:29][CH2:28]1.[Li+].[Cl-].N1C=C[CH:38]=[CH:37][CH:36]=1>>[CH3:12][CH:10]([CH3:11])[CH2:9][CH2:8][NH:7][C:5](=[O:6])[C:4]1[CH:3]=[C:2]([NH:1][C:23]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:24])[CH:15]=[C:14]([NH:16][C:31]([CH:30]2[CH2:38][CH2:37][CH2:36][CH2:28][CH2:29]2)=[O:32])[CH:13]=1

Participants

6

Reactant 5

HCID 1049PyridineHCID 13387N-methyl-2-pyrrolidoneHCID 75938Cyclohexanecarbonyl chlorideHCID 433294Lithium ChlorideHCID 61092537HCID 61092537, compound

Product 1

HCID 58903278HCID 58903278, compound

Procedure

from 0.63 g (2.85 mmol) of 3,5-diamino-N-(3-methylbutyl)-benzamide, 0.97 g (6.62 mmol) of cyclohexanecarbonylchloride, 30 ml of NMP, 5 ml of pyridine and 0.05 g of LiCl according to Method A.

Sources & evidence

ORD record
ord-1a1fb9f74fba4294a67a86688d0b6751
Source dataset
uspto-grants-2010_09
Patent number
US07790793B2

Reaction notes

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