Pyridine → HCID 58903246, compound

HRID 1711806Notes

Reaction equation

HRID 1711806 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:13]=[C:14]([NH2:16])[CH:15]=1)[C:5]([NH:7][CH:8]1[CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:6].[CH3:17][CH:18]([CH3:23])[CH2:19][C:20](Cl)=[O:21].CN1[C:29](=[O:30])[CH2:28][CH2:27][CH2:26]1.[Li+].[Cl-].N1C=CC=C[CH:34]=1>>[CH:8]1([NH:7][C:5](=[O:6])[C:4]2[CH:13]=[C:14]([NH:16][C:20](=[O:21])[CH2:19][CH:18]([CH3:23])[CH3:17])[CH:15]=[C:2]([NH:1][C:29](=[O:30])[CH2:28][CH:27]([CH3:34])[CH3:26])[CH:3]=2)[CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 13387N-methyl-2-pyrrolidoneHCID 66054Isovaleryl chlorideHCID 433294Lithium ChlorideHCID 61090893HCID 61090893, compound

Product 1

HCID 58903246HCID 58903246, compound

Procedure

from 0.50 g (2.28 mmol) of 3,5-diamino-N-cyclopentyl-benzamide, 0.64 g (5.31 mmol) of 3-methylbutyric acid chloride, 30 ml of NMP, 5 ml of pyridine and 0,05 g of LiCl according to Method A.

Sources & evidence

ORD record
ord-a8922bb4ec6a44c1a3329197f9fbb34f
Source dataset
uspto-grants-2010_09
Patent number
US07790793B2

Reaction notes

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