Pyridine → HCID 58903286, compound

HRID 1711810Notes

Reaction equation

HRID 1711810 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([CH:14]=[C:15]([NH2:17])[CH:16]=1)[C:5]([NH:7][CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1)=[O:6].[CH:18]1([C:24](Cl)=[O:25])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1.CN1[C:32](=[O:33])[CH2:31][CH2:30][CH2:29]1.[Li+].[Cl-].N1C=C[CH:39]=[CH:38][CH:37]=1>>[CH:8]1([NH:7][C:5](=[O:6])[C:4]2[CH:14]=[C:15]([NH:17][C:24]([CH:18]3[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]3)=[O:25])[CH:16]=[C:2]([NH:1][C:32]([CH:31]3[CH2:39][CH2:38][CH2:37][CH2:29][CH2:30]3)=[O:33])[CH:3]=2)[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 13387N-methyl-2-pyrrolidoneHCID 75938Cyclohexanecarbonyl chlorideHCID 433294Lithium ChlorideHCID 838200HCID 838200, compound

Product 1

HCID 58903286HCID 58903286, compound

Procedure

from 0.50 g (2.14 mmol) of 3,5-diamino-N-cyclohexyl-benzamide, 0.73 g (4.98 mmol) of cyclohexanecarbonylchloride, 30 ml of NMP, 5 ml of pyridine and 0.05 g of LiCl according to Method A.

Sources & evidence

ORD record
ord-f0aaae96d6904000b31ed56eda5e4fa8
Source dataset
uspto-grants-2010_09
Patent number
US07790793B2

Reaction notes

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