Phenylacetylene → HCID 11301032, compound

HRID 1711991Notes

Reaction equation

O=C1O[C@H]([C@H](CO)O)C([O-])=C1O.[Na+].[C:14]1([C:20]#[CH:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH:22](=[C:26]1[C:31](=[O:32])[O:30][C:29]([CH3:34])([CH3:33])[O:28][C:27]1=[O:35])[CH:23]([CH3:25])[CH3:24]>O.ClCCl.O.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[CH:23]([C@H:22]([CH:26]1[C:27](=[O:35])[O:28][C:29]([CH3:33])([CH3:34])[O:30][C:31]1=[O:32])[C:21]#[C:20][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([CH3:25])[CH3:24]

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of copper (II) acetate monohydrate (5.0 mg, 0.025 mmol) in water (0.2 ml) was treated with sodium (L)-ascorbate (10 mg, 0.050 mmol), the mixture was stirred until the mixture was turned bright orange (3 min). Subsequently, (R,M)-3-{[4-(2-diphenylphosphanyl-7-methoxy-naphthalen-1-yl)-phthalazin-1-ylamino]-phenyl-methyl}-pentan-3-ol (1st diastereomer, 16.5 mg, 0.025 mmol) and phenylacetylene (0.275 ml, 2.5 mmol) were added, the resulting mixture was stirred for 10 min at 23° C., cooled to 0° C., stirred for 5 min and treated with 5-isobutylidene-2,2-dimethyl-1,3-dioxane-4,6-dione (50 mg, 0.25 mmol). The reaction mixture was stirred vigorously at 0° C. for 14 hrs, diluted with dichloromethane (2 ml) and subjected directly to flash chromatography on silica gel (hexane/EtOAc 3:1) to give 71 mg of the pure title compound as a white solid. (yield: 94%)

Workup

customorange (3 min)
stirringthe resulting mixture was stirred for 10 min at 23° C.
stirringstirred for 5 min
stirringThe reaction mixture was stirred vigorously at 0° C. for 14 hrs

Sources & evidence

ORD record: ord-727eafecd7d84d1684359b6e4ad8ebec
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790882B2

Reaction notes

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