Phenylacetylene → HCID 12173662, compound

HRID 1711995Notes

Reaction equation

O=C1O[C@H]([C@H](CO)O)C([O-])=C1O.[Na+].[C:14]1([C:20]#[CH:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[CH:22](=[C:25]1[C:30](=[O:31])[O:29][C:28]([CH3:33])([CH3:32])[O:27][C:26]1=[O:34])[CH2:23][CH3:24]>O.ClCCl.O.C([O-])(=O)C.[Cu+2].C([O-])(=O)C>[CH2:23]([C@H:22]([CH:25]1[C:26](=[O:34])[O:27][C:28]([CH3:33])([CH3:32])[O:29][C:30]1=[O:31])[C:21]#[C:20][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[CH3:24]

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of copper (II) acetate monohydrate (10 mg, 0.050 mmol) in water (0.2 ml) was treated with sodium (L)-ascorbate (20 mg, 0.10 mmol), the mixture was stirred until the mixture was turned bright orange (3 min). Subsequently, (R,M)-3-{[4-(2-diphenylphosphanyl-7-methoxy-naphthalen-1-yl)-phthalazin-1-ylamino]-phenyl-methyl}-pentan-3-ol (1st diastereomer, 33.1 mg, 0.050 mmol) and phenylacetylene (0.275 ml, 2.5 mmol) were added, the resulting mixture was stirred for 10 min at 23° C., cooled to 0° C., stirred for 5 min and treated with 5-(1-propylidene)-2,2-dimethyl-1,3-dioxane-4,6-dione (46 mg, 0.25 mmol). The reaction mixture was stirred vigorously at 0° C. for 24 hrs, diluted with dichloromethane (2 ml) and subjected directly to flash chromatography on silica gel (hexane/EtOAc 3:1-2:1) to give 59 mg of the pure title compound as a white solid. (yield: 83%)

Workup

customorange (3 min)
stirringthe resulting mixture was stirred for 10 min at 23° C.
stirringstirred for 5 min
stirringThe reaction mixture was stirred vigorously at 0° C. for 24 hrs

Sources & evidence

ORD record: ord-977cbae7c1a54131bc060da2c01aaef4
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790882B2

Reaction notes

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