Cyclopropylamine → HCID 66569255, compound

HRID 1712000Notes

Reaction equation

[CH:1]1([NH2:4])[CH2:3][CH2:2]1.C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].O=[C:20]1[CH2:25][CH2:24][N:23]([C:26]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[O:27])[CH2:22][CH2:21]1>>[CH:1]1([NH:4][CH:20]2[CH2:25][CH2:24][N:23]([C:26]([O:28][CH2:29][C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=3)=[O:27])[CH2:22][CH2:21]2)[CH2:3][CH2:2]1

Participants

Reactant 3

HCID 69828Cyclopropylamine

HCID 643496Benzyl 4-oxopiperidine-1-carboxylate

HCID 5049666Sodium triacetoxyborohydride

Product 1

HCID 66569255HCID 66569255, compound

Procedure

Cyclopropylamine and sodium triacetoxy borohydride were added to a 1,2-dichloromethane solution of benzyl 4-oxopiperidine-1-carboxylate to obtain benzyl 4-(cyclopropylamino)piperidine-1-carboxylate.

Sources & evidence

ORD record: ord-30926d8aea97475782c07cc96bf08e4c
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07790884B2

Reaction notes

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