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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1712001Generated: November 4, 2026

1-Hydroxybenzotriazole → HCID 68505948, compound

https://huagongshe.com/reaction/1712001

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-HydroxybenzotriazoleHCID 75771—
ReactantN-Methyl-L-prolineHCID 643474—
Reactant1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 2723939—
Reactanttert-Butyl 4-(methylamino)piperidine-1-carboxylateHCID 15380702—
ProductHCID 68505948HCID 68505948—

Reaction Steps

By allowing tert-butyl 4-(methylamino)piperidine-1-carboxylate to react with EDCI hydrochloride, HOBt and 1-methyl-L-proline, tert-butyl 4-[methyl(1-methyl-L-prolyl)amino]piperidine-1-carboxylate was obtained. Then, trifluoroacetic acid was added thereto to obtain N,1-dimethyl-N-piperidin-4-yl-L-prolinamide.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07790884B2
Source datasetuspto-grants-2010_09
ORD IDord-ee29027c4384445d8e016a8b92f45b07
Source noteuspto-grants-2010_09