1-Hydroxybenzotriazole → HCID 68505948, compound

HRID 1712001Notes

Reaction equation

HRID 1712001 reaction equation
[CH3:1][NH:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1.CCN=C=NCCCN(C)C.Cl.C1C=CC2N(O)N=NC=2C=1.[CH3:38][N:39]1[CH2:46][CH2:45][CH2:44][C@H:40]1[C:41](O)=[O:42]>>[CH3:1][N:2]([C:41](=[O:42])[C@@H:40]1[CH2:44][CH2:45][CH2:46][N:39]1[CH3:38])[CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1

Participants

5

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 643474N-Methyl-L-prolineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 15380702tert-Butyl 4-(methylamino)piperidine-1-carboxylate

Product 1

HCID 68505948HCID 68505948, compound

Procedure

By allowing tert-butyl 4-(methylamino)piperidine-1-carboxylate to react with EDCI hydrochloride, HOBt and 1-methyl-L-proline, tert-butyl 4-[methyl(1-methyl-L-prolyl)amino]piperidine-1-carboxylate was obtained. Then, trifluoroacetic acid was added thereto to obtain N,1-dimethyl-N-piperidin-4-yl-L-prolinamide.

Sources & evidence

ORD record
ord-ee29027c4384445d8e016a8b92f45b07
Source dataset
uspto-grants-2010_09
Patent number
US07790884B2

Reaction notes

Loading…