6-Bromohexanoic acid → HCID 178433620, compound

HRID 1712019Notes

Reaction equation

HRID 1712019 reaction equation
[CH3:1][C:2]1[C:3]([CH3:12])([CH3:11])[C:4]2[C:5]([N:10]=1)=[N:6][CH:7]=[CH:8][CH:9]=2.[Br:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=[O:20]>C(OCC)(=O)C>[Br-:13].[C:19]([CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][N:6]1[CH:7]=[CH:8][CH:9]=[C:4]2[C:3]([CH3:12])([CH3:11])[CH:2]([CH3:1])[NH+:10]=[C:5]12)([OH:21])=[O:20]

Participants

4

Reactant 2

HCID 202106-Bromohexanoic acidHCID 222668362,3,3-Trimethyl-3H-pyrrolo[2,3-b]pyridine

Product 1

HCID 178433620HCID 178433620, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of 0.54 g of 2,3,3-trimethyl-3H-pyrrolo[2,3-b]pyridine and 1.32 g of 6-bromohexanoic acid is heated at 120° C. for one hour. Ethyl acetate (10 mL) is added, and the reaction mixture is heated at reflux for 15 minutes, then cooled to room temperature. The supernatant liquid is decanted to yield the product.

Workup

  1. temperaturethe reaction mixture is heated
  2. temperatureat reflux for 15 minutes
  3. temperaturecooled to room temperature
  4. customThe supernatant liquid is decanted
  5. customto yield the product

Sources & evidence

ORD record
ord-d1c9654cebc447cb9d82a9211d056648
Source dataset
uspto-grants-2010_09
Patent number
US07790893B2

Reaction notes

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