3-(Trifluoromethyl)benzoyl chloride → [3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-(3-trifluoromethylphenyl)-methanone

HRID 1712033Notes

Reaction equation

HRID 1712033 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[C:6](Cl)=[O:7].[CH3:14][O:15][C:16]1[CH:17]=[C:18]([C:22]2([OH:28])[CH2:27][CH2:26][CH2:25][NH:24][CH2:23]2)[CH:19]=[CH:20][CH:21]=1>>[OH:28][C:22]1([C:18]2[CH:19]=[CH:20][CH:21]=[C:16]([O:15][CH3:14])[CH:17]=2)[CH2:27][CH2:26][CH2:25][N:24]([C:6]([C:5]2[CH:9]=[CH:10][CH:11]=[C:3]([C:2]([F:13])([F:12])[F:1])[CH:4]=2)=[O:7])[CH2:23]1

Participants

3

Reactant 2

HCID 752573-(Trifluoromethyl)benzoyl chlorideHCID 116516763-(3-Methoxy-phenyl)-piperidine-3-ol

Product 1

HCID 11516422[3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-(3-trifluoromethylphenyl)-methanone

Procedure

The compound of Example 10 was prepared according to the general preparation protocol A from 3-trifluoromethylbenzoyl chloride and 3-(3-methoxy-phenyl)-piperidine-3-ol.

Sources & evidence

ORD record
ord-1a362c78e53642a3b14ef16fd6bf730e
Source dataset
uspto-grants-2010_09
Patent number
US07790898B2

Reaction notes

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