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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1712033Generated: October 26, 2026

3-(Trifluoromethyl)benzoyl chloride → [3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-(3-trifluoromethylphenyl)-methanone

https://huagongshe.com/reaction/1712033

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)benzoyl chlorideHCID 75257—
Reactant3-(3-Methoxy-phenyl)-piperidine-3-olHCID 11651676—
Product[3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-(3-trifluoromethylphenyl)-methanoneHCID 11516422—

Reaction Steps

The compound of Example 10 was prepared according to the general preparation protocol A from 3-trifluoromethylbenzoyl chloride and 3-(3-methoxy-phenyl)-piperidine-3-ol.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07790898B2
Source datasetuspto-grants-2010_09
ORD IDord-1a362c78e53642a3b14ef16fd6bf730e
Source noteuspto-grants-2010_09