2-Thiophenecarbonyl chloride → [3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-thiophen-2-yl-methanone

HRID 1712035Notes

Reaction equation

HRID 1712035 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6](Cl)=[O:7].[CH3:9][O:10][C:11]1[CH:12]=[C:13]([C:17]2([OH:23])[CH2:22][CH2:21][CH2:20][NH:19][CH2:18]2)[CH:14]=[CH:15][CH:16]=1>>[OH:23][C:17]1([C:13]2[CH:14]=[CH:15][CH:16]=[C:11]([O:10][CH3:9])[CH:12]=2)[CH2:22][CH2:21][CH2:20][N:19]([C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[O:7])[CH2:18]1

Participants

3

Reactant 2

HCID 789282-Thiophenecarbonyl chlorideHCID 116516763-(3-Methoxy-phenyl)-piperidine-3-ol

Product 1

HCID 11536987[3-Hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-thiophen-2-yl-methanone

Procedure

The compound of Example 14 was prepared according to the general preparation protocol A from thiophene-2-carbonyl chloride and 3-(3-methoxy-phenyl)-piperidine-3-ol.

Sources & evidence

ORD record
ord-622c623594e4484d991492aefea8144f
Source dataset
uspto-grants-2010_09
Patent number
US07790898B2

Reaction notes

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