2,4-Dichlorobenzoyl chloride → (2,4-Dichlorophenyl)-[3-hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-methanone

HRID 1712045Notes

Reaction equation

HRID 1712045 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[CH3:12][O:13][C:14]1[CH:15]=[C:16]([C:20]2([OH:26])[CH2:25][CH2:24][CH2:23][NH:22][CH2:21]2)[CH:17]=[CH:18][CH:19]=1>>[Cl:1][C:2]1[CH:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([N:22]1[CH2:23][CH2:24][CH2:25][C:20]([OH:26])([C:16]2[CH:17]=[CH:18][CH:19]=[C:14]([O:13][CH3:12])[CH:15]=2)[CH2:21]1)=[O:5]

Participants

3

Reactant 2

HCID 666452,4-Dichlorobenzoyl chlorideHCID 116516763-(3-Methoxy-phenyl)-piperidine-3-ol

Product 1

HCID 11574443(2,4-Dichlorophenyl)-[3-hydroxy-3-(3-methoxyphenyl)-piperidine-1-yl]-methanone

Procedure

The compound of Example 24 was prepared according to the general preparation protocol A from 2,4-dichlorobenzoyl chloride and 3-(3-methoxy-phenyl)-piperidine-3-ol.

Sources & evidence

ORD record
ord-cea58139ad6c483bac1fef17e8ad4098
Source dataset
uspto-grants-2010_09
Patent number
US07790898B2

Reaction notes

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