1-Chloro-3-methoxypropane → 7-Hydroxymethyl-1-(3-methoxypropyl)-3,4-dihydro-1H-quinolin-2-one

HRID 1712265노트

반응식

HRID 1712265 반응식
[OH:1][CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][C:9](=[O:13])[NH:10]2)=[CH:5][CH:4]=1.Cl[CH2:15][CH2:16][CH2:17][O:18][CH3:19]>>[OH:1][CH2:2][C:3]1[CH:12]=[C:11]2[C:6]([CH2:7][CH2:8][C:9](=[O:13])[N:10]2[CH2:15][CH2:16][CH2:17][O:18][CH3:19])=[CH:5][CH:4]=1

참가 물질

3

반응물 2

HCID 1189271-Chloro-3-methoxypropaneHCID 533933487-(Hydroxymethyl)-3,4-dihydroquinolin-2(1H)-one

생성물 1

HCID 685012247-Hydroxymethyl-1-(3-methoxypropyl)-3,4-dihydro-1H-quinolin-2-one

실험 절차

Analogously to Example 2c, 1.28 g of 7-hydroxymethyl-3,4-dihydro-1H-quinolin-2-one are reacted with 1.59 ml of 1-chloro-3-methoxypropane. The title compound is obtained as a slightly yellowish oil. Rf=0.24 (dichloromethane-methanol=95:5); Rt=2.71.

출처 및 근거

ORD 기록
ord-8c6d042e6e3841cf9e4a4c20722b67d8
출처 데이터셋
uspto-grants-2010_09
특허 번호
US07790715B2

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