HRID1712506

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：Cc1ccc(S(=O)(=O)[O-])cc1.c1cc[nH+]cc1

HCID466102

未命名化合物

结构：CC(C)[Si](OCCN1C(=O)COc2ccc(COC3CCCCO3)cc21)(C(C)C)C(C)C

HCID68500095

未命名化合物

PRODUCTS

生成物

结构：CC(C)[Si](OCCN1C(=O)COc2ccc(CO)cc21)(C(C)C)C(C)C

HCID68501294

6-Hydroxymethyl-4-(2-triisopropylsilanyloxyethyl)-4H-benzo[1,4]oxazin-3-one

C20H33NO4Si

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

CONDITIONS

反应条件

温度: 60 °C

PROCEDURE

实验过程

The solution of 7.24 g of 6-(tetrahydropyran-2-yloxymethyl)-4-(2-triisopropylsilanyloxyethyl)-4H-benzo[1,4]oxazin-3-one in 130 ml of ethanol is admixed with 0.392 g of pyridinium p-toluenesulphonate and stirred at 60° C. over 3 hours. The reaction mixture is cooled and concentrated by evaporation. The title compound is obtained as a colourless oil from the residue by means of flash chromatography (SiO2 60F). Rf=0.48 (1:1 EtOAc-heptane); Rt=5.51.

WORKUP

后处理

temperatureThe reaction mixture is cooled
concentrationconcentrated by evaporation