HCID 22340531, compound → HCID 68499094, compound

HRID 1712570Notes

Reaction equation

HRID 1712570 reaction equation
[OH:1][CH:2]1[CH:7]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:6][CH2:5][N:4]([C:15]([O:17][CH2:18][C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)=[O:16])[CH2:3]1.[N:25]1([C:29]([O-:31])=[O:30])[CH2:28][CH2:27][CH2:26]1>>[C:7]([O:30][C:29]([N:25]1[CH2:28][CH:27]([O:14][C:11]2[CH:10]=[CH:9][C:8]([CH:7]3[CH2:6][CH2:5][N:4]([C:15]([O:17][CH2:18][C:19]4[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=4)=[O:16])[CH2:3][CH:2]3[OH:1])=[CH:13][CH:12]=2)[CH2:26]1)=[O:31])([CH3:8])([CH3:2])[CH3:6]

Participants

3

Reactant 2

HCID 22340531HCID 22340531, compoundHCID 68500730Benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidinecarboxylate

Product 1

HCID 68499094HCID 68499094, compound

Procedure

Analogously to Method I, 9.170 g of benzyl 3-hydroxy-4-(4-hydroxyphenyl)piperidinecarboxylate and 11.00 g of tertbutyl 3-toluenesulphonyloxy)azetidine-1-carboxylate are reacted. The title compound is obtained as a yellow oil. Rf=023 (3:1 EtOAc-heptane); Rt=5.01.

Sources & evidence

ORD record
ord-b93493bd349c4f4c8bd9a86574c0494e
Source dataset
uspto-grants-2010_09
Patent number
US07790715B2

Reaction notes

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