Water → HCID 86626004, compound

HRID 1712909Notes

Reaction equation

HRID 1712909 reaction equation
C(N(C(C)C)CC)(C)C.[CH3:10][S:11](Cl)(=[O:13])=[O:12].[OH:15][CH2:16][CH2:17][O:18][CH:19]([C:28]1[NH:29][CH:30]=[N:31][CH:32]=1)[C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=1.O>ClCCl>[CH3:10][S:11]([O:15][CH2:16][CH2:17][O:18][CH:19]([C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][CH:21]=1)[C:28]1[NH:29][CH:30]=[N:31][CH:32]=1)(=[O:13])=[O:12]

Participants

6

Reactant 4

HCID 962WaterHCID 31297Methanesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 68440362HCID 68440362, compound

Product 1

HCID 86626004HCID 86626004, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

1.44 mmol of diisopropylethylamine and 1.20 mmol of methanesulphonyl chloride are added to a solution of 1.20 mmol of 4-[(2-hydroxyethoxy)-(3H-imidazol-4-yl)methyl]benzonitrile in 10 ml of dichloromethane at 0° C. The reaction mixture is stirred at 0° C. for 3 hours, tipped into water and extracted with dichloromethane. The combined organic phases are washed with brine, dried over sodium sulphate and evaporated. The crude title compound is used without further purification in the next stage.

Workup

  1. extractionextracted with dichloromethane
  2. washThe combined organic phases are washed with brine
  3. dry with materialdried over sodium sulphate
  4. customevaporated
  5. customThe crude title compound is used without further purification in the next stage

Sources & evidence

ORD record
ord-9d4ab9bcb1394299a2b4639f2f156c55
Source dataset
uspto-grants-2010_09
Patent number
US07795253B2

Reaction notes

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