HRID1712966
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
HCl (0.16 mL, 5.4 mmol) was added to a solution of tert-butyl [2-(5-{[5-(2-hydroxyphenyl)-3-pyrazin-2-yl-4,5-dihydro-1H-pyrazol-1-yl]carbonyl}-2-thienyl)benzyl]carbamate (0.030 g, 0.054 mmol) in MeOH (1 mL) over the course of 3 h at rt. A white precipitate formed and was filtered and dried under vacuum to give 2-[1-({5-[2-(aminomethyl)phenyl]-2-thienyl}carbonyl)-3-pyrazin-2-yl-4,5-dihydro-1H-pyrazol-5-yl]phenol (I-205), (25 mg). LCMS: (FA) ES+ 456.1.
WORKUP
后处理
- customA white precipitate formed
- filtrationwas filtered
- customdried under vacuum