Hydrochloric Acid → HCID 59463379, compound

HRID 1712966Notes

Reaction equation

HRID 1712966 reaction equation
Cl.[OH:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH:9]1[N:13]([C:14]([C:16]2[S:20][C:19]([C:21]3[CH:35]=[CH:34][CH:33]=[CH:32][C:22]=3[CH2:23][NH:24]C(=O)OC(C)(C)C)=[CH:18][CH:17]=2)=[O:15])[N:12]=[C:11]([C:36]2[CH:41]=[N:40][CH:39]=[CH:38][N:37]=2)[CH2:10]1>CO>[NH2:24][CH2:23][C:22]1[CH:32]=[CH:33][CH:34]=[CH:35][C:21]=1[C:19]1[S:20][C:16]([C:14]([N:13]2[CH:9]([C:4]3[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=3[OH:2])[CH2:10][C:11]([C:36]3[CH:41]=[N:40][CH:39]=[CH:38][N:37]=3)=[N:12]2)=[O:15])=[CH:17][CH:18]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59463177HCID 59463177, compound

Product 1

HCID 59463379HCID 59463379, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

HCl (0.16 mL, 5.4 mmol) was added to a solution of tert-butyl [2-(5-{[5-(2-hydroxyphenyl)-3-pyrazin-2-yl-4,5-dihydro-1H-pyrazol-1-yl]carbonyl}-2-thienyl)benzyl]carbamate (0.030 g, 0.054 mmol) in MeOH (1 mL) over the course of 3 h at rt. A white precipitate formed and was filtered and dried under vacuum to give 2-[1-({5-[2-(aminomethyl)phenyl]-2-thienyl}carbonyl)-3-pyrazin-2-yl-4,5-dihydro-1H-pyrazol-5-yl]phenol (I-205), (25 mg). LCMS: (FA) ES+ 456.1.

Workup

  1. customA white precipitate formed
  2. filtrationwas filtered
  3. customdried under vacuum

Sources & evidence

ORD record
ord-ae204f323c4c43e1bbf7dc9d1e29bfd9
Source dataset
uspto-grants-2010_09
Patent number
US07795249B2

Reaction notes

Loading…