反应详情

To 160 mL of chlorosulfonic acid cooled to 0° C. under nitrogen is added the title A compound, phenylacetic acid ethyl ester (59 g, 0.35 mol) over a period of 1 h. Reaction temperature is brought to RT (28° C.), then stirred at ambient temperature for 18 h. The reaction is poured onto ice, extracted with ethyl acetate, dried over MgSO4, filtered and evaporated to a yellow oil and used directly in the next step.

1. customReaction temperature
2. customis brought to RT
3. custom(28° C.)
4. additionThe reaction is poured onto ice
5. extractionextracted with ethyl acetate
6. dry with materialdried over MgSO4
7. filtrationfiltered
8. customevaporated to a yellow oil