Ethyl phenylacetate → (4-Chlorosulfonyl-phenyl)-acetic acid ethyl ester

Participants

Reaction Steps

To 160 mL of chlorosulfonic acid cooled to 0° C. under nitrogen is added the title A compound, phenylacetic acid ethyl ester (59 g, 0.35 mol) over a period of 1 h. Reaction temperature is brought to RT (28° C.), then stirred at ambient temperature for 18 h. The reaction is poured onto ice, extracted with ethyl acetate, dried over MgSO4, filtered and evaporated to a yellow oil and used directly in the next step.

Provenance & Evidence