HCID 86618328, compound → HCID 12527106, compound

HRID 1713018Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:22])[C:5]([N:19]=[N+]=[N-])=[CH:6][C:7]1[O:8][C:9]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)=[CH:10][CH:11]=1)[CH3:2]>CC1C=CC(C)=CC=1>[CH2:1]([O:3][C:4]([C:5]1[NH:19][C:11]2[CH:10]=[C:9]([C:12]3[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=3)[O:8][C:7]=2[CH:6]=1)=[O:22])[CH3:2]

Participants

Conditions

Temperature: 140 °C

Procedure

The obtained 2-Azido-3-[5-(4-chloro-phenyl)-furan-2-yl]-acrylic acid ethyl ester (21 mg, 0.066 mmol) was dissolved in p-xylene and the mixture was heated to 140° C. for half an hour. The solvent was thereafter evaporated to give 15 mg (78% yield) of 2-(4-chloro-phenyl)-4H-furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester as a red solid.

Workup

customThe solvent was thereafter evaporated

Sources & evidence

ORD record: ord-972ab5d505ed4d17b6d249215dc8e4ba
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795255B2

Reaction notes

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