Water → HCID 11718040, compound

HRID 1713019Notes

Reaction equation

HRID 1713019 reaction equation
C([O:3][C:4](=[O:30])[CH:5](CC)[CH2:6][CH2:7][N:8]1[C:25](=[S:26])[N:11]2[C:12]3[CH:13]=[C:14]([C:18]4[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=4)[O:15][C:16]=3[CH:17]=[C:10]2[C:9]1=[O:27])C.O>C(O)(C(F)(F)F)=O>[Cl:24][C:21]1[CH:22]=[CH:23][C:18]([C:14]2[O:15][C:16]3[CH:17]=[C:10]4[C:9](=[O:27])[N:8]([CH2:7][CH2:6][CH2:5][C:4]([OH:30])=[O:3])[C:25](=[S:26])[N:11]4[C:12]=3[CH:13]=2)=[CH:19][CH:20]=1

Participants

4

Reactant 2

HCID 962Water2×HCID 86618329HCID 86618329, compound

Product 1

HCID 11718040HCID 11718040, compoundYield 91.9%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Conditions

Temperature
70 °C

Procedure

Compound 4 (17.5 mg, 0.042 mmol) was dissolved in TFA (2 ml), to give a clear red solution. Water (0.5 ml) was added and the mixture was heated at 70° C. overnight. Additional water (2 ml) was added and the solvents of the reaction mixture reaction mixture were evaporated under reduced pressure to afford Compound 5 as a yellow-brown solid (15 mg, 90% yield).

Workup

  1. customto give a clear red solution
  2. customthe solvents of the reaction mixture reaction mixture
  3. customwere evaporated under reduced pressure

Sources & evidence

ORD record
ord-41d7cc2e74474c9abaff361b57198796
Source dataset
uspto-grants-2010_09
Patent number
US07795255B2

Reaction notes

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