Hydrochloric Acid → 4-Amino-3,3-dimethylbutanoic acid hydrochloride

HRID 1713020Notes

Reaction equation

HRID 1713020 reaction equation
[CH3:1][C:2]1([CH3:8])[CH2:6][NH:5][C:4](=[O:7])[CH2:3]1.[ClH:9].[OH2:10]>>[ClH:9].[NH2:5][CH2:6][C:2]([CH3:8])([CH3:1])[CH2:3][C:4]([OH:10])=[O:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 6375934,4-Dimethyl-2-pyrrolidinone

Product 1

HCID 144354354-Amino-3,3-dimethylbutanoic acid hydrochlorideYield 92%

Conditions

Temperature
120 °C

Procedure

4,4-Dimethyl-2-pyrrolidinone (2.52 grams, 22.3 mmol) was added to a mixture of concentrated HCl (50 ml) and water (50 ml) and the resulting mixture refluxed at 120° C. for 20 hours. After cooling to room temperature the mixture was washed twice with dichloromethane. The aqueous layer was evaporated to give 4-amino-3,3-dimethyl-butyric acid hydrochloride (3.425 grams, 92% yield) as a white solid.

Workup

  1. temperatureAfter cooling to room temperature the mixture
  2. washwas washed twice with dichloromethane
  3. customThe aqueous layer was evaporated

Sources & evidence

ORD record
ord-f4223b2e130340c9b22a6f684421d72c
Source dataset
uspto-grants-2010_09
Patent number
US07795255B2

Reaction notes

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