反应详情

温度

90 °C

Compound 7 (300 mg, 0.66 mmol) was dissolved in trifluoroacetic acid (TFA, 9 ml). Water (3 ml) was added and the resulting mixture was heated at 90° C. for 16 hours. The reaction mixture was then filtered, washed with ethanol and the solvents were evaporated under reduced pressure to give Compound 8 (234 mg, 83% yield) as an orange solid.

1. filtrationThe reaction mixture was then filtered
2. washwashed with ethanol
3. customthe solvents were evaporated under reduced pressure