6-Methoxy-1,2,3,4-tetrahydroisoquinoline → 1,2,3,4-Tetrahydroisoquinolin-6-ol

Participants

Reaction Conditions

Reaction Steps

6-Methoxy-1,2,3,4-tetrahydroisoquinoline (14.7 g, 90 mmol) is dissolved into hydrobromic acid (48%, 300 ml), and the mixture is heated at 120° C. for 16 hr. The solvent is removed under reduced pressure to give the title compound as the hydrobromate.

Provenance & Evidence