6-Methoxy-1,2,3,4-tetrahydroisoquinoline → 1,2,3,4-Tetrahydroisoquinolin-6-ol

HRID 1713082Notes

Reaction equation

HRID 1713082 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2>Br>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2

Participants

3

Reactant 1

HCID 393566-Methoxy-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 266981,2,3,4-Tetrahydroisoquinolin-6-ol

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Conditions

Temperature
120 °C

Procedure

6-Methoxy-1,2,3,4-tetrahydroisoquinoline (14.7 g, 90 mmol) is dissolved into hydrobromic acid (48%, 300 ml), and the mixture is heated at 120° C. for 16 hr. The solvent is removed under reduced pressure to give the title compound as the hydrobromate.

Workup

  1. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-cab8167cd527437c831c7a26e77faa68
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

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