Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | [6-(6-methyl-pyridazin-3-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester | HCID 59463569 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59463651 | HCID 59463651 | — |
Reaction Steps
To a stirred solution of [6-(6-methyl-pyridazin-3-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester (957 mg, 2.82 mmol) in EtOAc (30 ml), is added the solution of hydrochloride in dioxane (4.0M, 10 ml, 40 mmol). The mixture is stirred at 50° C. overnight. The organic solvents are evaporated to give the title compound as dihydrochloric acid salt. MS (+VE) m/z 284.1 (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07795262B2 |
|---|
| Source dataset | uspto-grants-2010_09 |
|---|
| ORD ID | ord-d09d2ad0d2fa410cbeadab49c98bdaf5 |
|---|
| Source note | uspto-grants-2010_09 |
|---|
