Hydrochloric Acid → HCID 59463651, compound

HRID 1713099Notes

Reaction equation

HRID 1713099 reaction equation
C([O:5][C:6](=[O:25])[CH2:7][N:8]1[CH2:17][CH2:16][C:15]2[C:10](=[CH:11][CH:12]=[C:13]([C:18]3[N:19]=[N:20][C:21]([CH3:24])=[CH:22][CH:23]=3)[CH:14]=2)[CH2:9]1)(C)(C)C.Cl.O1CCOCC1>CCOC(C)=O>[CH3:24][C:21]1[N:20]=[N:19][C:18]([C:13]2[CH:14]=[C:15]3[C:10](=[CH:11][CH:12]=2)[CH2:9][N:8]([CH2:7][C:6]([OH:25])=[O:5])[CH2:17][CH2:16]3)=[CH:23][CH:22]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 59463569HCID 59463569, compound

Product 1

HCID 59463651HCID 59463651, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
50 °C

Procedure

To a stirred solution of [6-(6-methyl-pyridazin-3-yl)-3,4-dihydro-1H-isoquinolin-2-yl]-acetic acid tert-butyl ester (957 mg, 2.82 mmol) in EtOAc (30 ml), is added the solution of hydrochloride in dioxane (4.0M, 10 ml, 40 mmol). The mixture is stirred at 50° C. overnight. The organic solvents are evaporated to give the title compound as dihydrochloric acid salt. MS (+VE) m/z 284.1 (M++1).

Workup

  1. customThe organic solvents are evaporated

Sources & evidence

ORD record
ord-d09d2ad0d2fa410cbeadab49c98bdaf5
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

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