Hydrochloric Acid → HCID 57420572, compound

HRID 1713113Notes

Reaction equation

HRID 1713113 reaction equation
[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][N:9](C(OC(C)(C)C)=O)[CH2:8][CH2:7][C:6]=2[N:5]=[CH:4][N:3]=1.Cl>C(Cl)Cl.O1CCOCC1>[Cl:1][C:2]1[C:12]2[CH2:11][CH2:10][NH:9][CH2:8][CH2:7][C:6]=2[N:5]=[CH:4][N:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 39345748tert-Butyl 4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate

Product 1

HCID 57420572HCID 57420572, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 4-chloro-5,6,8,9-tetrahydro-7H-pyrimido[4,5-d]azepine-7-carboxylate (2.0 g, 7.1 mmol) in DCM, a solution of 4N HCl in dioxane (10 mL) is added. The mixture is stirred for 4 hr at rt. The solvent is removed under vacuum to give the title compound (dichloride salt) as a white solid.

Workup

  1. customThe solvent is removed under vacuum

Sources & evidence

ORD record
ord-55cd7012a2ab41b093cac867c02097aa
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

Loading…