Hydrochloric Acid → HCID 66877005, compound

HRID 1713137Notes

Reaction equation

HRID 1713137 reaction equation
C([O:5][C:6](=[O:23])[CH2:7][N:8]1[CH2:17][C:16]2[N:15]=[CH:14][C:13]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:12][C:11]=2[CH2:10][CH2:9]1)(C)(C)C.[ClH:24]>O1CCOCC1>[ClH:24].[CH2:21]([O:20][C:18]([C:13]1[CH:14]=[N:15][C:16]2[CH2:17][N:8]([CH2:7][C:6]([OH:23])=[O:5])[CH2:9][CH2:10][C:11]=2[CH:12]=1)=[O:19])[CH3:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59463562HCID 59463562, compound

Product 1

HCID 66877005HCID 66877005, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of ethyl 7-(2-tert-butoxy-2-oxoethyl)-5,6,7,8-tetrahydro-1,7-naphthyridine-3-carboxylate (657 mg, 2.05 mmol) in dioxane (10 mL) is added 4 N HCl in dioxane (5 ml, 20 mmol) and the mixture is stirred at rt overnight. The solvent is removed and the residue is washed with ether to give the title compound as a white solid. MS (M+1): 265.1.

Workup

  1. customThe solvent is removed
  2. washthe residue is washed with ether

Sources & evidence

ORD record
ord-a26bb9e55ff44f63bfd8c219250993e5
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

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