HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Bromo-4,5,6,7-tetrahydro(1,3)thiazolo(5,4-c)pyridine, N-BOC protected | HCID 11162951 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-Bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride | HCID 17750404 | — |
Reaction Steps
To a solution of tert-butyl 2-bromo-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carboxylate (4.01 g, 12.56 mmol) in dioxane (20 ml) is added 4N HCl in dioxane (20 mL, 80 mmol), and the mixture is stirred at rt overnight. The solvent is removed and the residue is washed with ether to give a white solid. MS (M+1): 218.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07795262B2 |
| Source dataset | uspto-grants-2010_09 |
| ORD ID | ord-014d5987ad2b4abd8b78e91ba121f1eb |
| Source note | uspto-grants-2010_09 |