Hydrochloric Acid → 2-Bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride

HRID 1713152Notes

Reaction equation

HRID 1713152 reaction equation
[Br:1][C:2]1[S:3][C:4]2[CH2:5][N:6](C(OC(C)(C)C)=O)[CH2:7][CH2:8][C:9]=2[N:10]=1.[ClH:18]>O1CCOCC1>[ClH:18].[Br:1][C:2]1[S:3][C:4]2[CH2:5][NH:6][CH2:7][CH2:8][C:9]=2[N:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 111629512-Bromo-4,5,6,7-tetrahydro(1,3)thiazolo(5,4-c)pyridine, N-BOC protected

Product 1

HCID 177504042-Bromo-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl 2-bromo-6,7-dihydro[1,3]thiazolo[5,4-c]pyridine-5(4H)-carboxylate (4.01 g, 12.56 mmol) in dioxane (20 ml) is added 4N HCl in dioxane (20 mL, 80 mmol), and the mixture is stirred at rt overnight. The solvent is removed and the residue is washed with ether to give a white solid. MS (M+1): 218.9.

Workup

  1. customThe solvent is removed
  2. washthe residue is washed with ether
  3. customto give a white solid

Sources & evidence

ORD record
ord-014d5987ad2b4abd8b78e91ba121f1eb
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

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