Hydrochloric Acid → 1-(6-chloropyridazin-3-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride

HRID 1713159Notes

Reaction equation

HRID 1713159 reaction equation
[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[C:16]3[CH2:15][CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12][C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1.Cl>O1CCOCC1>[ClH:1].[Cl:1][C:2]1[N:7]=[N:6][C:5]([N:8]2[C:16]3[CH2:15][CH2:14][NH:13][CH2:12][C:11]=3[CH:10]=[N:9]2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 59463615tert-butyl 1-(6-chloropyridazin-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate

Product 1

HCID 866154151-(6-chloropyridazin-3-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl 1-(6-chloropyridazin-3-yl)-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate (2.14 g, 6.4 mmol) in dioxane (20 ml) is added 4N HCl in dioxane (20 mL, 80 mmol), and the mixture is stirred at rt overnight. The solvent is removed and the residue is washed with ether to give the title compound as a white solid. MS (M+1): 236.1.

Workup

  1. customThe solvent is removed
  2. washthe residue is washed with ether

Sources & evidence

ORD record
ord-a8e4eee639cb4942beb71245ba5174cb
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

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