Potassium Carbonate → HCID 57420588, compound

HRID 1713166Notes

Reaction equation

HRID 1713166 reaction equation
Cl.[CH:2]1([NH:7][NH2:8])[CH2:6][CH2:5][CH2:4][CH2:3]1.[C:9]([N:16]1[CH2:21][CH2:20][C:19](=O)[CH2:18][CH2:17]1)([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10].C([O-])([O-])=O.[K+].[K+]>CCO>[CH:2]1([NH:7][N:8]=[C:19]2[CH2:20][CH2:21][N:16]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:17][CH2:18]2)[CH2:6][CH2:5][CH2:4][CH2:3]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 212349Cyclopentylhydrazine hydrochlorideHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 57420588HCID 57420588, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of cyclopentylhydrazine hydrochloride (1.07 g, 7.83 mmol), Boc-4-piperidone (1.57 g, 7.86 mmol) and K2CO3 (2.2 g, 16 mmol) in EtOH (20 mL) is heated at reflux for 3 hr. The mixture is filtered and the filtrated is concentrated to give the title compound as an oil that is used in the next step without further purification. MS (M+1): 282.2.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 3 hr
  3. filtrationThe mixture is filtered
  4. concentrationthe filtrated is concentrated

Sources & evidence

ORD record
ord-1cf00fc4db36412aac058adad7525c5e
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

Loading…