Hydrochloric Acid → 2-cyclopentyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine hydrochloride

HRID 1713169Notes

Reaction equation

HRID 1713169 reaction equation
[CH:1]1([N:6]2[CH:21]=[C:9]3[CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12][CH2:13][C:8]3=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:22]>O1CCOCC1>[ClH:22].[CH:1]1([N:6]2[CH:21]=[C:9]3[CH2:10][NH:11][CH2:12][CH2:13][C:8]3=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57356886tert-butyl 2-cyclopentyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate

Product 1

HCID 574499462-cyclopentyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

To a solution of tert-butyl 2-cyclopentyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate (720 g, 2.47 mmol) in dioxane (5 mL) is added 4N HCl in dioxane (5 mL, 20 mmol) and the mixture is stirred at rt overnight. The solvent is removed and the residue is washed with ether to give the title compound as a white solid. MS (M+1): 192.1

Workup

  1. customThe solvent is removed
  2. washthe residue is washed with ether

Sources & evidence

ORD record
ord-4bbb66c662c046418a3691e47d2b29df
Source dataset
uspto-grants-2010_09
Patent number
US07795262B2

Reaction notes

Loading…