反应详情

A mixture of 8-bromoadenosine (0.100 g), 4-bromobenzylamine hydrochloride (0.193 g) and triethylamine (0.201 mL) in ethanol (2.9 mL) was stirred under reflux for 96 hours. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by column chromatography on aminopropylated silica gel (eluent: dichloromethane/methanol=10/1) to give the title compound (0.118 g).

1. temperatureunder reflux for 96 hours
2. concentrationconcentrated under reduced pressure
3. customThe residue was purified by column chromatography on aminopropylated silica gel (eluent: dichloromethane/methanol=10/1)