Phenylboronic Acid → 2-Fluoro-4-phenylbenzaldehyde

HRID 1713274Notes

Reaction equation

Br[C:2]1[CH:9]=[CH:8][C:5]([CH:6]=[O:7])=[C:4]([F:10])[CH:3]=1.[C:11]1(B(O)O)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[F:10][C:4]1[CH:3]=[C:2]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:9]=[CH:8][C:5]=1[CH:6]=[O:7]

Participants

Reactant 2

HCID 66827Phenylboronic Acid

HCID 1435174-Bromo-2-fluorobenzaldehyde

Product 1

HCID 167685272-Fluoro-4-phenylbenzaldehyde

Procedure

The title compound was prepared in a similar manner to that described in Reference Example 2 using 4-bromo-2-fluoro-benzaldehyde instead of tert-butyl N-(4-bromobenzyl)carbamate and phenylboronic acid instead of 3-benzyloxyphenylboronic acid.

Sources & evidence

ORD record: ord-c4321426f7b24bf6b6e58373ddac92b8
Source dataset: uspto-grants-2010_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07795236B2

Reaction notes

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