Benzyl Bromide → 2-(Benzyloxy)benzonitrile

HRID 1713287Notes

Reaction equation

HRID 1713287 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9])#[N:2].[CH2:10](Br)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>>[CH2:10]([O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:1]#[N:2])[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 119072-Hydroxybenzonitrile

Product 1

HCID 20640242-(Benzyloxy)benzonitrile

Procedure

The title compound was prepared in a similar manner to that described in Reference Example 20 using 2-cyanophenol instead of tert-butyl N-(3′-hydroxybiphenyl-4-ylmethyl)-carbamate and benzyl bromide instead of 1-bromopropane.

Sources & evidence

ORD record
ord-86a2ee45ab584d04badc95c8eab5de42
Source dataset
uspto-grants-2010_09
Patent number
US07795236B2

Reaction notes

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