Piperidin-4-ol → HCID 67542700, compound

HRID 1713308Notes

Reaction equation

HRID 1713308 reaction equation
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[C:10]([CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH:9]=[CH:8][C:7]=1[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1.[NH:27]1[CH2:32][CH2:31][CH:30]([OH:33])[CH2:29][CH2:28]1>>[OH:33][CH:30]1[CH2:31][CH2:32][N:27]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:11]=[C:10]([CH2:12][NH:13][C:14](=[O:20])[O:15][C:16]([CH3:19])([CH3:18])[CH3:17])[CH:9]=[CH:8][C:7]=2[C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)[CH2:28][CH2:29]1

Participants

3

Reactant 2

HCID 79341Piperidin-4-olHCID 67457175HCID 67457175, compound

Product 1

HCID 67542700HCID 67542700, compound

Procedure

The title compound was prepared in a similar manner to that described in Reference Example 139 using tert-butyl N-[2-(3-chloropropoxy)biphenyl-4-ylmethyl]carbamate instead of 3-(3-chloropropoxy)-4-phenylbenzonitrile and piperidine-4-ol instead of pyrrolidine.

Sources & evidence

ORD record
ord-4059d3852cf84752be834f5a072aff7e
Source dataset
uspto-grants-2010_09
Patent number
US07795236B2

Reaction notes

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