反应详情

To a solution of tert-butyl N-[2-(3-ethylaminopropoxy)-biphenyl-4-ylmethyl]carbamate (0.41 g) in tetrahydrofuran (4.0 mL) was added N-carbobenzoxyoxysuccinimide (0.260 g), and the resulting mixture was stirred at room temperature for 14 hours. The reaction mixture was concentrated under reduced pressure and the residue was purified by column chromatography on aminopropylated silica gel (eluent: hexane/ethyl acetate=2/1) to give the title compound (0.46 g).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was purified by column chromatography on aminopropylated silica gel (eluent: hexane/ethyl acetate=2/1)